Value of coagulation function related indicators in the prognosis of non-small cell lung cancer
10.3760/cma.j.cn114452-20200911-00722
- VernacularTitle:凝血功能相关检测指标在非小细胞肺癌患者中的预后价值
- Author:
Yunfei MA
;
Mingwei YU
;
Guangda LI
;
Yu GAO
;
Guowang YANG
;
Xiaomin WANG
- From:
Chinese Journal of Laboratory Medicine
2021;44(3):212-216
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical significance of coagulation function related indicators in the prognosis of non-small cell lung cancer.Methods:The clinical data of 248 patients with non-small cell lung cancer from June 2014 to December 2017 in the Department of Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, were retrospectively analyzed. The receiver operating characteristic (ROC) curve was used to determine the best cutoff values of prognostic indicators,the Cox regression model was used for multivariate analysis, and the Kaplan-Meier method was used for survival analysis.Results:ROC curve analysis showed that the best cutoff values for D-dimer (D-D), fibrinogen (FIB) and prothrombin time (PT)were 0.18 mg/L, 4.25 g/L and 12.0 s, respectively. Cox multivariate regression analysis showed that increased expression of D-D ( HR=1.197, 95% CI 1.100-1.303), PT ( HR=1.111, 95% CI 1.049-1.176) and FIB ( HR=1.510, 95% CI 1.276-1.788) were risk factors for the prognosis of non-small cell lung cancer ( P<0.001). Kaplan-Meier survival analysis results showed that the overall survival in the high expression group of D-D, FIB and PT was shorter than in of the low expression group ( P<0.001). Conclusion:D-D, PT and FIB are independent factors affecting the prognosis of non-small cell lung cancer.
