Progress in the application of circulating tumor RNA in clinical tumor diagnosis and treatment

VernacularTitle:循环肿瘤RNA在肿瘤临床诊疗中的应用进展
Author: Renquan LU ; Yanchun WANG ; Lin GUO
From: Chinese Journal of Laboratory Medicine 2021;44(3):191-196
CountryChina
Language:Chinese
Abstract: Liquid biopsy can non-invasively reveal the status of tumors and its prognosis in vivo, which is hotspots and difficulties of research in current era. Among them, an emerging marker called circulating tumor RNA (ctRNA) reflects the genetic information of tumor origin and provides a powerful basis for early diagnosis, targeted drug monitoring and prognosis prediction. At this stage, several ctRNA kits have been approved for clinical use. For example, microRNA (miRNA) can be used for aided diagnosis of liver cancer. And many transformation applications of promising ctRNA have been vigorously carried out. Despite the facts that there are still many clinical challenges of ctRNA detection technology to be solved effectively, ctRNA, as a new member of the liquid biopsy technology, has shown remarkable clinical value. Along with the mechanism becoming gradually clear, ctRNA will be a reliable diagnostic tool with the increasing clinical requirements for facilitating the tumor management.