The status and advances in the application of optical coherence tomography and optical coherence tomography angiography in Leber's hereditary optic neuropathy

VernacularTitle:光相干断层扫描及其血管成像在Leber遗传性视神经病变中的应用研究现状及进展
Author: Hongxia GONG
From: Chinese Journal of Ocular Fundus Diseases 2021;37(3):245-247
CountryChina
Language:Chinese
Abstract: Leber hereditary optic neuropathy is an optic neuropathy associated with mitochondrial DNA. The disease affects young men mainly, which is considered to be due to denaturation of the retinal nerve ganglion cell and axonal loss of optic nerve, leading to optic atrophy. Nowadays, there are some development in studying Leber hereditary optic neuropathy by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). It is great help to know the disease, forecast the progression of disease, and take action on intervention. In addition, there is a lack of in-depth study on OCT and OCTA characteristics among different mutation sites of LHON, different genders of the same site, different families of the same site or even different branches of the same family. It is expected to be improved in the future work.