Research progress in the role of monocyte chemoattractant protein-1 in diabetic retinopathy

VernacularTitle:单核细胞趋化蛋白-1在糖尿病视网膜病变中的作用研究进展
Author: Dalan JING ; Jie SU ; Wei WANG
From: Chinese Journal of Ocular Fundus Diseases 2021;37(1):77-81
CountryChina
Language:Chinese
Abstract: Diabetic retinopathy (DR) is one of the most common and serious diabetic complications, which is the main cause of vision loss in adults. The specific vascular and neuropathology mechanism of DR is not clear. It has been demonstrated that Inflammatory reaction might be take effects in the development and progression of DR. Monocyte chemoattractant protein-1 (MCP-1), as an important chemokine in the inflammatory response process, promotes chemotactic and activating factors, destroys the blood-retinal barrier, causes retinal vascular disease, and activates microglia, which is related to the severity of the disease. With further research on MCP-1, it is possible to use chemokines and their receptors as target cells to control or slow down the progression of DR by reducing or inhibiting the production of MCP-1 in diabetic patients in the early stages of the disease. This study can provide new ideas and new methods about preventing and treating DR.