The simulation of multiphase flow field in ventricular assist device and analysis of hemolytic capability

VernacularTitle:心室辅助装置多相流流场数值模拟及溶血性能分析
Author: Tieyan LI ; Lin ZOU ; Yuanfeng XIN ; Yunzhen FENG ; Yifei HUA ; Feng WAN ; Zhongmin LIU
From: Chinese Journal of Thoracic and Cardiovascular Surgery 2021;37(2):98-103
CountryChina
Language:Chinese
Abstract: Objective:The hemolytic prediction model of the axial flow impeller blood pump is carried out by using a computational fluid dynamics(CFD) multiphase flow model.Methods:The hydrodynamic performance of the pump and the flow field in the pump, and the shear stress distribution are analyzed. A hemolytic prediction model based on the shear stress is built based on the calculation results. Hemolysis tests in vitro were performed 6 times with fresh bovine blood. At each time, the flow of the ventricular assist device(VAD) is 5 L/min and the outflow tract pressure is 100 mmHg(13.3kPa). According to the tests, the plasma free hemoglobin(FHB) content and the hematocrit(HCT) are measured every half hour. At the end of each experiment Normal Index of Hemolysis(NIH) is calculated.Results:The average of NIH is 0.0055 g/100L, almost identical with that obtained from the hemolytic prediction model.Conclusion:Multiphase flow model can be used for quantitative predictions of the hemolytic behavior of a VAD. This method can be applied in the selection stage of a blood pump.