Application of magnetic nanoparticles in repair and regeneration of peripheral nerve
10.3760/cma.j.cn441206-20201202-00399
- VernacularTitle:磁性纳米粒子在周围神经再生与修复中的应用
- Author:
Yang WANG
;
Ting LIU
;
Laijin LU
- From:
Chinese Journal of Microsurgery
2021;44(2):237-240
- CountryChina
- Language:Chinese
-
Abstract:
Peripheral nerve injuries, the worldwide difficult and complicated diseases, cause serious dysfunction but without ideal strategies to assist the successful treatment and recovery. The primary strategy to repair the peripheral nerve injuries is to bridge the lesions by promoting axon regeneration. The importance of mechanical factors in the nervous system has been appreciated only recently. It has been demonstrated that the application of external mechanical force is able to direct axonal outgrowth and to stimulate axonal elongation. For this purpose, to direct axonal growth cones in vivo with accurate force appears to be a challenge that must be resolved. Bionanotechnology is promising a new tool that offers the possibility to influence the process of axonal regeneration. The magnetic force generated by the interaction between Magnetic nanoparticles (MNPs) and magnetic fields provides remote, non-invasive, accurate, and controllable lead and control of neuronal axon regeneration.
