Research progress on immunomodulatory effects and mechanisms of bacterial flagellin

VernacularTitle:细菌鞭毛蛋白免疫调节作用及机制的研究进展
Author: Zhenming XIAO ; Chao ZHAO ; Yonglin WU ; Jun XU
From: Chinese Journal of Microbiology and Immunology 2021;41(5):395-399
CountryChina
Language:Chinese
Abstract: Flagellum is a slender and wavy protein-attached filament on the surface of certain bacterial cells. It not only plays an important role in the movement and pathogenic ability of bacteria, but also participates in a variety of host immune regulation. Flagellin is a structural protein that forms the main part of flagellar filaments and can be recognized by TLR5 and other receptors in the host cell to induce the body′s immune response. At present, flagellin is widely used in the research of new immune adjuvants due to its immune activation, and its inflammation inhibitory effect also has good prospects against immune pathological damage. In this review, we summarized and analyzed the recent progress on the basic structure and function of flagellin, the host recognition mechanism, and its role in regulating the host immune system.