Status and prospects of rotavirus particle-like vaccines

VernacularTitle:轮状病毒颗粒样候选疫苗研究现状和展望
Author: Jialiang DU ; Yan LIU
From: Chinese Journal of Microbiology and Immunology 2021;41(5):388-394
CountryChina
Language:Chinese
Abstract: Human rotavirus (RV) is one of the main pathogens that cause non-bacterial acute gastroenteritis diseases globally. Live attenuated vaccine is an effective method to prevent RV infection. In order to improve the safety of RV vaccines, it is a good choice to develop other forms of vaccines other than live virus vaccines to avoid attenuated vaccine strains to restore virulence through back mutation or cause environmental contamination. This article reviews the research of RV virus like particle(VLP) vaccines.