Research progress in bacterial resistance to antibiotics analyzed based on MALDI-TOF MS mass peak

VernacularTitle:基于MALDI-TOF MS质谱峰分析细菌耐药性的研究进展
Author: Kewen TANG ; Congrong LI ; Qianyu WANG ; Dongling TANG
From: Chinese Journal of Microbiology and Immunology 2021;41(3):242-248
CountryChina
Language:Chinese
Abstract: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has become a widely used method in the field of microbial identification. Its obvious advantages including rapidity, great accuracy and high throughput attract many researchers to investigate its potential for usage in other microbiological fields. Currently, several studies have reported MALDI-TOF MS-based analysis of bacterial resistance to antibiotics, which can identify the specific heterogeneous spectrum peaks related to drug resistance through simple visual analysis of the spectrum or more complex analysis of the entire spectrum using informatics methods and statistical approaches. Therefore, MALDI-TOF MS has become a potential tool for detecting antibiotic resistance in bacteria. This review mainly summarized the progress in MALDI-TOF MS-based analysis of bacterial resistance to antibiotics.