Programmed cell death 1 and T lymphocyte immunity in chronic obstructive pulmonary disease
10.3760/cma.j.cn112309-20200713-00352
- VernacularTitle:程序性细胞死亡受体1与慢性阻塞性肺疾病中T淋巴细胞免疫
- Author:
Jianpeng ZHOU
;
Jingmin DENG
;
Minchao DUAN
- From:
Chinese Journal of Microbiology and Immunology
2021;41(3):237-241
- CountryChina
- Language:Chinese
-
Abstract:
T lymphocyte immune dysfunction plays an important role in the occurrence and development of chronic obstructive pulmonary disease (COPD), but the specific mechanism is not fully understood. Programmed cell death 1 (PD-1) negatively regulates the activation and effector function of T lymphocytes by binding to its ligand PD-L1, thus participating in the maintenance of immune tolerance. Recent studies have found that blocking the PD-1/PD-L1 signaling pathway can improve T-cell depletion and enhance the ability of anti-infection in COPD patients. Therefore, understanding the regulatory effects of PD-1 on T lymphocytes is of great significance to studying the pathogenesis and clinical treatment of COPD. This article briefly reviewed the research progress in PD-1 in terms of structure, function, T cell regulation and relationship with COPD.
