The role of IL-1 related receptor SIGIRR in immune related diseases

VernacularTitle:白细胞介素1相关受体SIGIRR在免疫相关疾病中的作用
Author: Rujia SI ; Ying SHI ; Junqi NIU
From: Chinese Journal of Microbiology and Immunology 2021;41(3):233-236
CountryChina
Language:Chinese
Abstract: SIGIRR, a member of the interleukin 1 receptor superfamily, is also known as a single immunoglobulin (Ig)-related receptor, which is believed to play a key role in the development of inflammation and the regulation of anti-inflammatory effects. Some studies believe that the abnormal down-regulation of SIGIRR can lead to intestinal inflammation, pyelonephritis, systemic lupus erythematosus and other diseases, but it can promote tumor growth and potentially cause anti-tumor immune damage when its genes are overexpressed. Therefore, the role of SIGIRR in disease occurrence and development is considered a double-edged sword. At present, the detailed molecular mechanism of SIGIRR′s biological role is not fully understood. This article reviews the functions of SIGIRR in the occurrence and development of immune-related diseases and immune regulation, as well as related cell signaling pathways, which have been discovered and confirmed.