Dual role of high mobility group box 1 (HMGB1) in tumor progression

VernacularTitle:高迁移率族蛋白B1在肿瘤中的双重作用
Author: Yueqi CHEN ; Zhaoliang SU ; Lin XIA
From: Chinese Journal of Microbiology and Immunology 2021;41(3):221-225
CountryChina
Language:Chinese
Abstract: High mobility group box 1 (HMGB1), a ubiquitous non-histone protein in the nuclear chromatin of eukaryotic cells, plays an important role in inflammatory diseases, autoimmune diseases and cancer. The function of HMGB1 in the development and progression of tumor varies with its subcellular localization. On one hand, HMGB1 promotes the growth, proliferation, invasion and metastasis of tumor cells, and mediates immune escape and immune tolerance; on the other hand, HMGB1 possesses anti-tumor activity by maintaining the stability of genome, regulating the expression of tumor suppressor genes, inhibiting cell invasion and metastasis and improving the anti-tumor therapeutic effect. In recent years, increasing evidences have suggested that HMGB1 is closely associated with the development of tumor. Therefore, understanding the function of HMGB1 in cancer will provide enlightenment for preventive and therapeutic strategies. This review summarized the dual role of HMGB1 in tumor progression.