Research progress in characteristics of B cells in high-, low- and non-responsive individuals after HBV vaccination
10.3760/cma.j.cn112309-20200207-00052
- VernacularTitle:HBV疫苗接种后高、低、无应答个体B细胞特征的研究进展
- Author:
Tingwen YANG
;
Lina SUN
;
Xiaoyan HE
;
Xinsheng YAO
- From:
Chinese Journal of Microbiology and Immunology
2021;41(2):159-164
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) infection remains a serious global health problem, which can lead to acute and chronic liver diseases and a variety of complications. HBV vaccination, which induces B cells to secrete protective hepatitis B surface antibody (HBsAb), is an important measure to prevent HBV infection. Some studies have shown that different individuals have different responses to HBV vaccine, which can be divided into ultra-high/high, normal/medium and low/non-response. Research on the potential mechanisms can provide reference for the preparation of high-titer HBsAb and the prevention and treatment of HBV infection. This paper reviewed the research situation and progress in the characteristics and mechanism of B cells in different responders after HBV vaccination.
