Progress in microRNA regulating apoptosis of Mycobacterium tuberculosis-infected macrophages

VernacularTitle:microRNA调控结核分枝杆菌感染巨噬细胞凋亡的研究进展
Author: Fanglu WANG ; Wentao WANG ; Zhengjun YI ; Yurong FU
From: Chinese Journal of Microbiology and Immunology 2021;41(2):143-148
CountryChina
Language:Chinese
Abstract: Apoptosis is particularly important for the body to inhibit or eliminate Mycobacterium tuberculosis ( Mtb) infection. A series of mechanisms to regulate macrophage apoptosis are triggered after macrophages are infected by Mtb. In Mtb-infected macrophages, there are differentially expressed microRNAs (miRNAs), which can directly bind to the binding sites in the 3′-untranslated region (3′ UTR) of apoptotic genes to regulate the expression of apoptotic genes and the apoptosis of macrophages through the mitochondrial or death receptor pathway. This paper reviewed the miRNAs associated with the apoptosis of Mtb-infected macrophages and the major mechanisms.