Function and formation mechanism of neutrophil extracellular traps in related diseases
10.3760/cma.j.cn112309-20200116-00031
- VernacularTitle:中性粒细胞胞外诱捕网产生的分子机制及其在相关疾病中的作用
- Author:
Di WANG
;
Jing WU
;
Li YU
;
Xiao XIAO
;
Fengmin ZHANG
- From:
Chinese Journal of Microbiology and Immunology
2021;41(1):69-73
- CountryChina
- Language:Chinese
-
Abstract:
Neutrophil extracellular traps (NETs) are fibrous structures released by neutrophils and the formation process is called NETosis. NETs participate in the host innate immunity. Recent research has found that NETs is a double-edged sword. Under normal conditions, the formation of NETs can play a role in clearing pathogens and maintain the host homeostasis. However, when NETs are overproduced or not cleared in time, they can take part in the pathogenesis of many diseases. This article reviewed the formation of NETs, the mechanisms involved in NETosis and the role of NETs in the secretion of multiple cytokines in different diseases.
