Changes of somatosensory evoked potentials in spinal cord injury and the influence of the timing of decompression on the recovery of spinal cord function and evoked potentials
10.3760/cma.j.issn.0254-1424.2021.01.002
- VernacularTitle:脊髓减压对脊髓损伤后大鼠体感诱发电位的影响
- Author:
Xiaofeng SONG
;
Changcheng ZHANG
;
Ruifeng YIN
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2021;43(1):7-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the changes in somatosensory evoked potential (SEP) in rats with spinal cord injury (SCI) and the effects of relieving spinal cord compression at different times on recovery and the evoked potential.Methods:Seventy Sprague-Dawley rats were randomly divided into a control group of 10 and an experimental group of 60. The experimental group was further divided into a mild injury group of 10, a moderate injury group of 40 and a severe injury group of 10. Spinal cord injuries with different severities were established in the experimental group using a self-made percussion device. The rats′ SEPs were measured before the injury, and 5 minutes, 1 hour, 6 hours, 3 days and 7 days afterward. Some of the rats receiving decompression treatment.Results:The more seriously the spinal cord was injured, the longer was the latency and the smaller was the amplitude. Both differences were statistically significant. Rats with longer compression time had significantly longer incubation periods and greater decreases in the amplitude. After relieving the compression, rats from whom it had been relieved earlier had quicker amplitude recovery. For rats under compression for 30 minutes, their amplitude was the lowest seven days later.Conclusions:For spinal cord injury, longer compression time can lead to more significant changes in the latency and amplitude of SEP, with the change in the amplitude more significant than that in the latency.
