Progress of cell-free fetal RNA in maternal plasma in prediction of preeclampsia
10.3760/cma.j.cn113903-20200812-00789
- VernacularTitle:母体外周血胎儿游离RNA在子痫前期预测中的研究进展
- Author:
Shanshan LI
;
Wen LI
;
Yongmei SHEN
;
Xiaomin ZHAO
;
Lei ZHANG
;
Ying CHANG
- From:
Chinese Journal of Perinatal Medicine
2021;24(4):310-313
- CountryChina
- Language:Chinese
-
Abstract:
Due to the advantages of being unaffected by fetal gender, ease of detection, and good stability, circulating cell-free fetal RNA (cffRNA) is a potential biomarker in obstetric practice. Current evidence has shown that placenta is the main source of circulating cffRNA. In view of the abnormal expression levels in women with preeclampsia and intrauterine growth restriction, circulating cffRNA is proposed as a potential tool to predict or diagnose these diseases. A summary of the molecular characteristics and the applications in preeclampsia of circulating cffRNA is reviewed, in order to evaluate the hypothesis for the prediction of preeclampsia by cffRNA.
