Advances in the diagnosis and treatment of dipeptidyl-peptidase-like protein 6 antibody- associated encephalitis
10.3760/cma.j.cn113694-20200702-00495
- VernacularTitle:二肽基肽酶样蛋白-6抗体相关脑炎临床诊治进展
- Author:
Erchuang LI
;
Yinxi ZHANG
;
Meiping DING
- From:
Chinese Journal of Neurology
2021;54(4):424-428
- CountryChina
- Language:Chinese
-
Abstract:
Dipeptidyl-peptidase-like protein 6 (DPPX) antibody-associated encephalitis, mediated by DPPX antibodies in serum and/or cerebrospinal fluid, is a novel autoimmune encephalitis. It presents with multifocal and diverse neurological disorders characterized by the triad of prodromal weight loss and/or gastrointestinal symptoms (diarrhea predominately), cognitive-mental dysfunction, and central nervous system hyperexcitability. Brain magnetic resonance imaging shows non-specific abnormalities. Immunotherapy can result in clinical improvements, but the disease is prone to relapse.
