Research progress of anti-glutamic acid decarboxylase antibody-associated encephalitis
10.3760/cma.j.cn113694-20200724-00573
- VernacularTitle:抗谷氨酸脱羧酶抗体相关脑炎的研究进展
- Author:
Lulu YAN
;
Xiaoxue HUANG
;
Yao TANG
;
Shuang ZHANG
;
Jun WU
- From:
Chinese Journal of Neurology
2021;54(4):409-417
- CountryChina
- Language:Chinese
-
Abstract:
Anti-glutamic acid decarboxylase antibody-associated encephalitis is a kind of autoimmune encephalitis mediated by anti-glutamic acid decarboxylase antibody, which belongs to anti-neuronal intracellular synaptic protein antibody-associated encephalitis. Clinical manifestations include stiff-person syndrome, cerebellar ataxia, limbic encephalitis, seizures, etc., often associated with a variety of autoimmune diseases, rarely associated with tumors. Detection of anti-glutamic acid decarboxylase antibody is crucial for clinical diagnosis. Immunotherapy helps to relieve symptoms and improve prognosis. The incidence of this disease is low, and there are few reports at home and abroad. This paper intends to review the research on this encephalitis, hoping to improve the clinicians′ understanding and the level of diagnosis and treatment of the disease.
