Progress in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
10.3760/cma.j.cn113694-20200703-00503
- VernacularTitle:常染色体显性遗传脑动脉病伴皮质下梗死及白质脑病的发病机制研究进展
- Author:
Chen LING
;
Zhaoxia WANG
;
Yun YUAN
- From:
Chinese Journal of Neurology
2021;54(4):399-403
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary cerebral small vessel disease caused by NOTCH3 gene mutations. At present, the pathogenesis and the effective treatments of CADASIL is unclear. This review summarizes the existing pathogenesis of CADASIL, including the dysfunction of cerebral small arteries, the abnormalities of vascular smooth muscle cells, and the possible destruction of blood-brain barrier.
