Advances of motor unit number estimation and motor unit number index in amyotrophic lateral sclerosis
10.3760/cma.j.cn113694-20200612-00436
- VernacularTitle:肌萎缩侧索硬化的运动单位估数和运动单位数量指数检测技术的研究进展
- Author:
Tianmi YANG
;
Bei CAO
;
Huifang SHANG
- From:
Chinese Journal of Neurology
2021;54(3):290-296
- CountryChina
- Language:Chinese
-
Abstract:
Amyotrophic lateral sclerosis (ALS) is a rapid progressive neurodegenerative disease, characterized by the degeneration of both upper and lower motor neurons. The progressive motor unit loss due to lower motor neuron damage is one of the most important pathological process in ALS. However, there are lack of specific biomarkers for early diagnosis and progression monitoring of ALS. The relevant electrophysiologic techniques which quantify the number of motor unit have been developed rapidly in recent years. Among them, the motor unit number estimation (MUNE) and the motor unit number index (MUNIX) have been widely applied to quantify motor unit number loss in ALS. The most recent advances of MUNE and MUNIX in ALS were reviewed.
