Key role of low-density lipoprotein receptor-related protein 1 in peripheral clearance of beta amyloid
10.3760/cma.j.cn113694-20200418-00274
- VernacularTitle:低密度脂蛋白受体相关蛋白1在β淀粉样蛋白外周清除中的关键作用
- Author:
Ke WANG
;
Jianping QIN
;
Dan MENG
;
Pan CAI
- From:
Chinese Journal of Neurology
2021;54(3):272-276
- CountryChina
- Language:Chinese
-
Abstract:
The neurotoxin β-amyloid (Aβ) is the main hallmark of Alzheimer′s disease (AD). Recent evidence suggests that, in common sporadic or late-onset forms of AD, elevated brain Aβ levels are caused by impaired clearance rather than overproduction. The cell surface receptor′s low-density lipoprotein receptor-related protein-1 (LRP1) has been reported to not only play a role in Aβ endocytosis, but also exist in the blood-brain barrier system, peripheral blood, liver, kidney and other tissues and organs, and transport Aβ to the cerebrospinal fluid or blood system by passing through the blood-brain barrier or the blood-cerebrospinal fluid barrier effectively, and finally clear it out of the body through peripheral tissues and organs. In this review, the role of LRP1 in the peripheral transport and clearance of Aβ is described, and it may be a safe and effective way to reduce Aβ in the brain and even improve cognitive dysfunction.
