Analysis of the risk factors influencing the prognosis of patients with recurrent hepatocellular carcinoma after liver transplantation within Fudan criteria and summary of relevant clinical experience
10.3760/cma.j.cn421203-20210109-00018
- VernacularTitle:符合"复旦标准"的肝癌肝移植受者复发后生存状况及诊治策略
- Author:
Yifeng HE
;
Kang SONG
;
Guohuan YANG
;
Qiman SUN
;
Jian SUN
;
Yongsheng XIAO
;
Zheng WANG
;
Guoming SHI
;
Yinghong SHI
;
Xiaowu HUANG
;
Jia FAN
;
Jian ZHOU
- From:
Chinese Journal of Organ Transplantation
2021;42(2):82-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the risk factors influencing the prognosis for patients with hepatocellular carcinoma (HCC) recurrence after liver transplantation and summarize the relevant diagnostic and therapeutic experiences.Methods:The clinicopathological features with diagnosis and treatment plan of 102 recurrent HCC patients fulfilling the Fudan Criteria were compared for survival rate (univariate analysis) and independent prognostic indicators were obtained by Cox multivariate analysis.Results:The 1/3/5-year overall survival rates were 92.2%, 48.6% and 34.6% and the 1/3/5-year survival rates with tumor were 63.2%, 31.0% and 16.7% respectively. Cox regression analysis indicated that patient age, whether tumor can be surgically resected or not and personalized diagnostic & therapeutic plan based upon targeted therapy were independent prognostic factors affecting the overall survival rates and survival rates with tumor.Conclusions:Although HCC recurrence and metastasis after liver transplantation seriously influence patient prognosis, satisfactory outcomes may be obtained for some patients through active, effective and precise managements.
