Expression Pattern of Caspase 2 in Korean Gastric Cancers.
10.5230/jkgca.2003.3.1.38
- Author:
Chang Jae KIM
1
;
Jik Young PARK
;
Jong Heun LEE
;
Young Gu CHO
;
Jong Woo LEE
;
Young Hwa SONG
;
Young Sil KIM
;
Cho Hyun PARK
;
Suk Woo NAM
;
Sug Hyung LEE
;
Nam Jin YOO
;
Jung Young LEE
;
Won Sang PARK
Author Information
1. Department of Pathology, Medical Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea. wonsang@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Apoptosis;
Caspase;
Immunohistochemistry;
Stomach cancer
- MeSH:
Apoptosis;
Caspase 2*;
Cytoplasm;
Epithelial Cells;
Gastric Mucosa;
Humans;
Immunohistochemistry;
Lymph Nodes;
Lymphocytes;
Neoplasm Metastasis;
Peptide Hydrolases;
Stomach Neoplasms*;
United Nations
- From:Journal of the Korean Gastric Cancer Association
2003;3(1):38-43
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Caspase 2, a member of the family of ICE-like proteases, is activated by the Fas pathway and induces apoptosis by triggering the caspase cascade. The purpose of this study was to determine whether the expression pattern of caspase 2 might be associated with gastric cancer development and if so, to determine to which pathologic parameter it is linked. MATENRIALS AND METHODS: For the construction of the gastric cancer tissue microarray, 78 paraffin-embedded tissues containing gastric cancer areas were cored 3 times and transferred to the recipient master block. The expression pattern of caspase 2 was examined on tissue microarray slides by using immunohistochemistry and was compared with pathologic parameters, including histologic type, depth of invasion, lymph node metastasis, and peritoneal dissemination. RESULTS: Caspase 2 was expressed on superficial and foveolar epithelial cells and lymphocytes in the gastric mucosa, mainly in cytoplasm. We found loss of caspase 2 expression in 41 (52.6%) of the 78 gastric cancer tissues. Statistically, histologic type and other pathologic parameters were not related with loss of caspase 2 expression. CONCLUSION: Our findings provide enough evidence that loss of caspase 2 expression may contribute to the development of Korean gastric cancer and that it might be one of the possible escape mechanisms from apoptosis in gastric cancer.
