Predictive value of combined preoperative fibrinogen and neutrophil to lymphocyte ratio for the prognosis of pancreatic cancer patients after radical surgery

VernacularTitle:术前血浆纤维蛋白原联合中性粒细胞与淋巴细胞比值在评价可切除性胰腺癌患者预后中的价值
Author: Junfeng CHENG ; Xuemin LI ; Xiaokang WU ; Hui YUAN ; Shi′an YU
From: Chinese Journal of General Surgery 2021;36(2):110-113
CountryChina
Language:Chinese
Abstract: Objective:To evaluate the prediction value of preoperative Fibrinogen(FIB) in combination with neutrophil-lymphocyte ratio(NLR)for the prognosis of operable pancreatic cancer patients.Methods:The clinical data of 124 patients who underwent radical resection for pancreatic cancer in our hospital from Jan 2010 to Dec 2018 were retrospectively analyzed.The patients were divided into three groups according the high and low NLR, FIB value which defined by the receiver operating characteristic curve (ROC). The clinicopathological data and overall median survival time were compared between the three groups.Results:Univarate analysis showed that age, tumor stage, NLR, FIB and F-NLR score were associated with the prognosis( P<0.05), while multivariate analysis showed that high F-NLR score was the independent prognostic factor. The median survival time of patients with F-NLR scores 0, 1 and 2 group was 30.6, 20.3 and 13.9 months( P<0.05). The prognosis of high F-NLR score was significantly worse than that of low F-NLR score( P<0.05). Conclusions:A high preoperative F-NLR score was a promising predictor for the prognosis of pancreatic cancer patients after radical resection.