Neutrophil-lymphocyte-ratio in the prediction of the prognosis of neoadjuvant chemoradiotherapy for locally advanced rectal cancer
10.3760/cma.j.cn113855-20200630-00522
- VernacularTitle:中性粒细胞与淋巴细胞比值在预测局部进展期直肠癌同期新辅助放化疗效果中的价值
- Author:
Ning XU
;
Wenliang LI
;
Liang YIN
;
Yunfei ZHANG
;
Jingyu YANG
;
Fengchang HUANG
- From:
Chinese Journal of General Surgery
2021;36(2):86-89
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine whether the neutrophil-lymphocyte-ratio (NLR) a inflammatory factor can predict tumor response to neoadjuvant chemoradiotherapy (CRT) in locally advanced rectal cancer.Methods:Between 2014 and 2019, 205 locally advanced rectal cancer patients underwent CRT before curative surgery. After propensity score matching, 148 patients (74 matched pairs) were enrolled in this study. The hematological parameters were collected and their relationship with tumor response was investigated.Results:After propensity score matching, NLR before CRT in good response group were significantly lower than that in poor response group(2.2±1.0 vs. 2.4±1.2, Z=-2.465, P<0.05), while there was no significant difference in all hematological characteristics between two groups after CRT. The cutoff values of pre-CRT NLR was 3.88 after receiver operating characteristic analysis(AUC=0.618, 95% CI: 0.528-0.708). Multivariate analysis model indicated that pre-CRT NLR≥3.88 was the predictor of poor tumor response ( OR=5.826, 95% CI: 1.299-26.132, P<0.05). Conclusion:The increased NLR before CRT can be regarded as a hematological factor for poor tumor response in locally advanced rectal cancer.
