Therapeutic trauma-induced repigmentation of vitiligo lesions: mechanisms and relevant clinical studies
10.35541/cjd.20190876
- VernacularTitle:治疗性皮肤创伤诱导白癜风皮损复色的机制与临床研究进展
- Author:
Zhikai LIAO
;
Tiechi LEI
- From:
Chinese Journal of Dermatology
2021;54(3):267-269
- CountryChina
- Language:Chinese
-
Abstract:
It has long been noted that dermabrasion, plum-blossom needling or micro-needling, and even ablative fractional CO 2 laser can effectively induce repigmentation of vitiligo lesions resistant to conventional ultraviolet B phototherapy. In addition to trauma-induced increase in the transdermal absorption of drugs, these treatments also initiate wound repair and activate melanocytes in hair follicles or epidermis. Basal layer keratinocytes, vascular endothelial cells and fibroblasts in the wound margins can secrete chemokine CXCL12 to recruit melanocytes or melanocyte stem cells expressing chemokine receptors CXCR4/CXCR7 in the hair follicle bulge or around the skin lesions to move towards the vitiliginous area. This review summarizes progress in repigmentation of vitiligo lesions induced by therapeutic skin trauma.
