Application of JAK inhibitors in the treatment of refractory dermatomyositis
10.35541/cjd.20190899
- VernacularTitle:JAK抑制剂在难治性皮肌炎中的应用进展
- Author:
Weiwei HUA
;
Chunyan GONG
- From:
Chinese Journal of Dermatology
2021;54(3):264-267
- CountryChina
- Language:Chinese
-
Abstract:
The Janus kinase (JAK) /signal transducer and activator of transcription (STAT) signaling pathway plays an important role in the occurrence of dermatomyositis. JAK inhibitors can block signal transduction dependent on JAK/STAT pathway-related factors, and inhibit immune cell activation and T cell-mediated inflammatory responses. So far, the US Food and Drug Administration (FDA) has only approved rheumatic arthritis and myelofibrosis as the indications of JAK inhibitors, but there have been many reports on JAK inhibitors for the treatment of refractory dermatomyositis. This review summarizes the role of JAK/STAT pathway in the pathogenesis of dermatomyositis, the mechanism of action and clinical application of JAK inhibitors in the treatment of dermatomyositis.
