Role of microRNAs in inflammatory skin diseases
10.35541/cjd.20190864
- VernacularTitle:microRNA在炎症性皮肤病中作用的研究进展
- Author:
Ruixian YE
;
Rujun XUE
;
Jingyao LIANG
;
Huanyan LIU
;
Qiying XIONG
;
Liangjiao DONG
;
Xibao ZHANG
- From:
Chinese Journal of Dermatology
2021;54(2):178-182
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are a class of non-coding RNA molecules that regulate gene expression after transcription and participate in various pathophysiological processes in the skin. In recent years, it has been reported that changes in miRNA expression profiles are related to some inflammatory skin diseases. For example, miR-203, miR-146a and miR-21 are upregulated in psoriatic lesions, miR-155 and miR-146a are upregulated in atopic dermatitis lesions, miR-21, miR-223, miR-142-3p and miR142-5p are upregulated in allergic contact dermatitis lesions; however, miR-146a and miR-155 are downregulated in peripheral blood of patients with systemic lupus erythematosus, and miR-223 is downregulated in dermatomyositis lesions. This review summarizes relationships of miRNAs with the occurrence and development of some inflammatory skin diseases.
