Type 2 inflammatory responses in atopic dermatitis
10.35541/cjd.20201030
- VernacularTitle:特应性皮炎与2型炎症反应
- Author:
Yunsheng LIANG
;
Zhao LIU
- From:
Chinese Journal of Dermatology
2021;54(1):84-88
- CountryChina
- Language:Chinese
-
Abstract:
Studies have shown that the type 2 inflammatory response and related cytokines such as interleukin-4 and -13, play a key role in atopic dermatitis (AD) . Th2 cells and type 2 cytokines are the core factors in the type 2 inflammatory response, which is mainly involved in the pathogenesis of AD through 3 pathways: aggravating skin barrier defects; activating and strengthening the itching response; pathologically reprograming regulatory T cells into Th2-like regulatory T cells to amplify the type 2 inflammatory response. This review explores the relationship between the type 2 inflammatory response and AD, aiming to help optimize treatment regimens and provide new treatment options for patients with AD.
