A case-control study on the correlation between CD247 gene polymorphism and type 1 diabetes mellitus

VernacularTitle:CD247基因多态性与1型糖尿病的病例对照研究
Author: Xiaohao WANG ; Jialin LIANG ; Yujiao CHEN ; Ganxiong LIANG
From: Chinese Journal of Endocrinology and Metabolism 2021;37(5):453-456
CountryChina
Language:Chinese
Abstract: The blood samples of 294 Chinese Han patients with type 1 diabetes mellitus(T1DM) and 199 controls were collected and their genomic DNAs were extracted. The single nucleotide polymorphisms rs17534481, rs12095738, rs2988276, and rs6668182 of CD247 gene were detected. The results showed that rs17534481 polymorphism of CD247 gene was associated with T1DM in Chinese Han population, and T allele was a protective factor for type 1 diabetes mellitus( OR=0.667, P=0.037). There was no significant difference in genotype frequency and allele frequency of rs12095738, rs2988276, and rs6668182 between type 1 diabetes group and control group( P>0.05).