Association of serum lipocalin-2 level with cardiovascular disease in patients with type 2 diabetes
10.3760/cma.j.cn311282-20201216-00832
- VernacularTitle:2型糖尿病患者血清脂质运载蛋白2水平与心血管疾病的相关性研究
- Author:
Yu JING
;
Jie SHI
;
Bin LU
;
Weiwei ZHANG
;
Yehong YANG
;
Jie WEN
;
Renming HU
;
Zhen YANG
;
Xuanchun WANG
- From:
Chinese Journal of Endocrinology and Metabolism
2021;37(4):267-273
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between serum lipocalin-2 level and the risk of cardiovascular disease(CVD) in patients with type 2 diabetes.Methods:A total of 279 type 2 diabetic patients were enrolled in this study. Basic information and clinical data were collected. These patients were divided into CVD group and non-CVD group according to their cardiovascular disease status. Serum lipocalin-2 level was assessed by enzyme linked immunosorbent assay.Results:Compared to non-CVD group, serum lipocalin-2 level was significantly higher in CVD group( P<0.01). The Spearman correlation analysis showed that serum lipocalin-2 level was positively correlated with waist circumstance, diastolic blood pressure, uric acid, triglyceride, and HbA 1C( P<0.05), while negatively correlated with high density lipoprotein-cholesterol level( P<0.01). In addition, the univariate and multivariate logistic regression analysis revealed that serum lipocalin-2 was an independent risk factor for CVD( P<0.01)after adjustment for potential confounders. Moreover, receiver operating characteristic curve analysis demonstrated that the area under curve value of lipocalin-2 was 0.74, with the optimal cutoff value of lipocalin-2 66.84 ng/mL. Conclusion:Serum lipocalin-2 is closely associated with CVD in patients with type 2 diabetes, which might be considered as one of the predictors for CVD in type 2 diabetes mellitus.
