Central precocious puberty with primary pigmented nodular adrenocortical disease: One case report
10.3760/cma.j.cn311282-20200212-00057
- VernacularTitle:中枢性性早熟合并原发性色素沉着性结节性肾上腺皮质病一例报道
- Author:
Mingqiang ZHU
;
Guanping DONG
;
Ke HUANG
;
Xuefeng CHEN
;
Li ZHANG
;
Yangli DAI
;
Jinna YUAN
;
Wei WU
- From:
Chinese Journal of Endocrinology and Metabolism
2021;37(3):240-244
- CountryChina
- Language:Chinese
-
Abstract:
To report the clinical, imaging, and pathological feature of a rare case of central precocious puberty with primary pigmented nodular adrenocortical disease(PPNAD), and to conduct a retrospective analysis of PPNAD with relevant literatures. The pubic hair was found in the child for more than one year. Physical examination showed Cushing′s syndrome. ACTH in blood decreased, cortisol rhythm was disordered, 24-hour urine free cortisol increased and the paradoxical increase of urine free cortisol after high dose dexamethasone suppression test. Adrenal enhancement computed tomography(CT)showed multiple small nodular shadows in bilateral adrenal glands. Gonadotropin releasing hormone(GnRH)stimulation test supported central precocious puberty and GnRH analogue was used to control the sexual development. PPNAD was supported by pathology result. The symptoms of Cushing′s syndrome were relieved partially after left adrenalectomy.
