Research progress on the anti-infectious mechanism of vitamin D

VernacularTitle:维生素D抗感染机制研究进展
Author: Lei ZHANG ; Yanhu DONG
From: Chinese Journal of Endocrinology and Metabolism 2021;37(2):168-171
CountryChina
Language:Chinese
Abstract: Clinical epidemiological studies have shown that vitamin D deficiency is associated with infectious diseases, which is confirmed by recent studies implying the role of vitamin D as a key regulator of host defense against infections. Bioactive vitamin D triggers antimicrobial pathways against pathogens in mucous membrane and cells of the human innate immune system. In addition, vitamin D also attenuates excessive inflammation and acquired immunity, and thus limits collateral tissue damage. The observed effects of vitamin D on infectious diseases, particularly airway infections, should be addressed in the management of viral infections. Findings from cross-sectional studies should be confirmed by prospective research. In this review, we summarize the current knowledge regarding the effect of vitamin D on innate and acquired host defense against infections.