Relationship between metabolically healthy obesity and atherosclerosis

Ran Wei; Yuanyue Zhu; Chunyan HU; Hongyan QI; Yi Zhang; Rui DU; Jie Zhang; Jieli LU; Yufang BI; Yuhong Chen; Lin Lin

Return

Relationship between metabolically healthy obesity and atherosclerosis

VernacularTitle:代谢健康型肥胖与动脉粥样硬化的相关性研究
Author: Ran WEI ; Yuanyue ZHU ; Chunyan HU ; Hongyan QI ; Yi ZHANG ; Rui DU ; Jie ZHANG ; Jieli LU ; Yufang BI ; Yuhong CHEN ; Lin LIN
From: Chinese Journal of Endocrinology and Metabolism 2021;37(2):100-105
CountryChina
Language:Chinese
Abstract: Objective:To investigate the association between metabolically healthy obesity(MHO) and atherosclerosis risk among Chinese community population aged 40 or older.Methods:A total of 9 525 participants without cardiovascular diseases (3 621 men and 5 904 women) from Jiading community in Shanghai were enrolled to complete questionnaires, undergo extensive physical examination including brachial-ankle pulse wave velocity (baPWV) and blood pressure (BP) assessment, and laboratory screening. According to body mass index (BMI) and metabolic status, these participants were categorized into 4 groups including metabolically healthy non-obese (MHNO), metabolically unhealthy non-obese (MUNO), MHO, and metabolically unhealthy obese (MUO). High baPWV was defined as baPWV>1 400 mm/s, and high pulse pressure (PP) was defined as PP above fourth quartile of the population. Multivariate logistic regression model was conducted to explore the relationship between MHO and high baPWV as well as high PP after adjusting for confounders. Results:After multivariable adjustment, such as sex, age, current smoking, current drinking, and education, logistic regression analysis showed that MHO was significantly correlated with high baPWV ( OR=1.18, 95% CI 1.02-1.37) and high PP ( OR=1.72, 95% CI 1.43-2.08) in comparison with MHNO. Otherwise, both MUNO and MUO subjects were at higher risk for suffering from high baPWV (MUNO: OR=3.02, 95% CI 2.60-3.50; MUO: OR=3.26, 95% CI 2.87-3.70) and high PP (MUNO: OR=2.56, 95% CI 2.17-3.02; MUO: OR=3.49, 95% CI 3.01-4.06). Conclusion:On the basis of Chinese community population, there was a pronounced correlation between the MHO phenotype and the increased risk of developing atherosclerosis.