Association of muscle mass loss with atherosclerosis in elderly patients with type 2 diabetes
10.3760/cma.j.cn311282-20200310-00150
- VernacularTitle:老年2型糖尿病患者肌肉量减少与动脉粥样硬化的相关性分析
- Author:
Youran KONG
;
Xinxin ZHANG
;
Ming DUAN
;
Xufu WANG
;
Bingzi DONG
;
Xiaofang SUN
;
Yangang WANG
;
Ying YUAN
- From:
Chinese Journal of Endocrinology and Metabolism
2021;37(1):28-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of muscle mass loss with atherosclerosis in elderly patients with type 2 diabetes mellitus(T2DM).Methods:A total of 322 patients with T2DM aged≥60 years old were divided into muscle mass loss group( n=152) and non-muscle mass loss group( n=170) according to their appendicular skeletal muscle mass index(ASMI). All participants underwent physical examination, dual-energy X-ray absorptiometry check, carotid and lower extremity ultrasound, as well as laboratory tests. Results:Among 322 patients, 49(15.22%) patients were suffered from sarcopenia and 152(47.2%) patients with reduced muscle mass. The carotid and lower extremity atherosclerosis grades in the muscle mass loss group were significantly higher than those in the non-muscle mass loss group( P<0.05), with lower body mass index(BMI), T-score, ASMI, uric acid, and homeostasis model assessment of insulin resistance index( P<0.05). Multivariate logistic regression analysis showed that carotid atherosclerosis and lower extremity atherosclerosis were risk factors for muscle mass loss while BMI and 25-(OH)D 3 were protective factors for muscle mass loss. There existed a consistency in carotid atherosclerosis grade and lower extremity atherosclerosis grade of elderly patients with T2DM( P<0.01). Conclusion:Atherosclerosis has a predictive value for early sarcopenia in elderly patients with T2DM.
