The research progress of DNA methylation in bladder cancer
10.3760/cma.j.cn112330-20190812-00366
- VernacularTitle:DNA甲基化在膀胱癌诊治中的研究进展
- Author:
Ziwei WANG
;
Chuanliang XU
- From:
Chinese Journal of Urology
2021;42(4):312-315
- CountryChina
- Language:Chinese
-
Abstract:
Bladder cancer is a malignant tumor of the urinary system with the highest and still increasing incidence rate in China in recent years. While most patients with a diagnosis of non-muscle invasive bladder cancer (NMIBC) have a good prognosis, NMIBC is prone to relapse and progress to muscular invasive cancer (MIBC) after treatment, leading to a poor prognosis. At present, diagnosis and postoperative follow-up of bladder cancer still rely on invasive cystoscopy, and there is a lack of effective treatment for advanced tumors. The results show that methylation, as a chemical modification of DNA, is related to the occurrence and development of bladder cancers. This article reviews the research progress of bladder cancer DNA methylation in diagnosis, monitoring and treatment in recent years.
