A Xp11.2 translocations/TFE3 gene fusion renal cell carcinoma with metastasis administered by axitinib: a case report

VernacularTitle:转移性Xp11.2易位/TFE3基因融合相关性肾癌阿昔替尼治疗一例报告
Author: Taiping LENG ; Liang WANG ; Shadan LI ; Youguang ZHAO ; Jiwen LIU ; Qian LIU ; Shiyuan QIN
From: Chinese Journal of Urology 2021;42(4):302-303
CountryChina
Language:Chinese
Abstract: Xp11.2 translocation/TFE3 gene fusion-related renal cancer often affects young people, and lymph node metastasis is also common, with a good short-term prognosis. This article reports a 19-year-old young female with a huge metastatic Xp11.2 translocation/TFE3 gene fusion-related renal carcinoma, which metastasize to lung and lymph node. The patient underwent axitinib neoadjuvant targeted therapy before the operation. During the operation, lymph node metastasis was found and the para-aortic lymph node dissection was performed.After the operation, the patient continued to be treated with axitinib, and the lung metastases improved. There was no local recurrence and metastasis after 1 year follow-up.