Progress in research and application of molecular changes in prostate cancer in China and the West
10.3760/cma.j.cn112330-20201214-00819
- VernacularTitle:前列腺癌分子改变研究进展及中西方差异
- Author:
Jili ZHANG
;
Ziwei WANG
;
Wenhui ZHANG
;
Tao WANG
;
Jing LI
;
Xu GAO
- From:
Chinese Journal of Urology
2021;42(3):233-236
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, with the development of sequencing technology and research on molecular changes in different races of prostate cancer, it has been found that the pathogenesis of prostate cancer showed obvious ethnic differences. This article reviewed the research progress of ETS fusion genes, FOXA1, SPOP, IDH1 and other driver genes in prostate cancer. And the research of molecular typing of prostate cancer showed different patterns of molecular changes in Chinese and western populations. The molecular changes of prostate cancer in western populations were dominated by ETS fusion gene, while those in Chinese populations were dominated by gene mutations, mainly FOXA1 and SPOP mutations. Moreover, the dominant fusion gene in Chinese prostate cancer was not ETS fusion gene, but SCHLAP1-UBE2E3.
