An evaluation of the diagnostic value of coronary angiography-based fractional flow reserve versus the wire-based fractional flow reserve in elderly patients with stable ischemic heart disease
10.3760/cma.j.issn.0254-9026.2021.04.011
- VernacularTitle:老年冠心病患者冠状动脉造影血流储备分数与导丝血流储备分数诊断价值的评价
- Author:
Hu AI
;
Naixin ZHENG
;
Le LI
;
Guojian YANG
;
Hui LI
;
Guodong TANG
;
Huiping ZHANG
;
Ying ZHAO
;
Fucheng SUN
- From:
Chinese Journal of Geriatrics
2021;40(4):459-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the diagnostic value of coronary angiography-based fractional flow reserve(caFFR)versus a wire-based fractional flow reserve(FFR)in elderly patients with stable ischemic heart disease.Methods:A total of 168 patients(186 vessels)who underwent a pressure wire(PW)-based FFR measurement from Jan.2015 to Dec.2019 in Beijing hospital were enrolled and analyzed retrospectively.Coronary angiography images and matched steady-state aortic pressure of patients were sent to the core laboratory for caFFR measurement under the blind method.All patients were divided into the non-elderly group(<65 years, n=93)and the elderly group(≥65 years, n=75). The diagnostic value of caFFR was evaluated by using the wire-based FFR cut-off value of ≤0.80 as the reference standard.The correlation and consistency of caFFR and wire-based FFR were analyzed, and compared between the non-elderly and elderly groups.Results:The caFFR had a good correlation and consistency with wire-based FFR in the elderly group( r=0.796, P<0.01). In non-aged versus elderly groups, diagnostic accuracy of caFFR was 91.9% versus 93.1%, diagnostic sensitivity of caFFR was 91.8% vs.93.2%, diagnostic specificity of caFFR was 92.3% vs.93.0%, all P>0.05.The area under the receiver-operating characteristic curve of caFFR had no significant difference between the non-elderly and elderly patients(0.964 vs.0.972, Z=0.00823, 95% CI: -0.037-0.052, P>0.05). Conclusions:The caFFR has a good diagnostic correlation and consistency with wire-based FFR in the elderly group, and caFFR's diagnostic performance in the elderly is similar to that in the non-elderly patients.
