The role of nicotinamide adenine dinucleotide phosphate oxidase in vascular cognitive impairment and its mechanism: a research progress
10.3760/cma.j.issn.0254-9026.2021.02.026
- VernacularTitle:尼克酰胺腺嘌呤二核苷酸磷酸氧化酶在血管性认知障碍中的作用及其机制的研究进展
- Author:
Weijiao ZHANG
;
Wei ZHANG
- From:
Chinese Journal of Geriatrics
2021;40(2):255-259
- CountryChina
- Language:Chinese
-
Abstract:
Oxidative stress(OS)is one of the factors leading to vascular cognitive impairment(VCI). Reactive oxygen species(ROS)produced by Nicotinamide adenine dinucleotide phosphate oxidase(NOX)is an important pathogenic molecule of VCI.Risk factors for VCI such as hyperglycemia and decomposition/re-implantation always increases an upstream NOX activation.Other risk factors such as advanced age, hypertension and stroke are the downstream damage caused by NOX-dependent ROS.The causes of VCI include both risk factors related to NOX and the cell damage caused by NOX-dependent ROS.Studies have shown that the inhibiting of NOX activity can reduce cognitive impairment and the risk factors in animal models of VCI.In this article, we review the research progress of the role and mechanism of NOX in VCI.
