Research advances in effects of mitochondria-associated endoplasmic reticulum membranes on Alzheimer's disease and Parkinson's disease

VernacularTitle:线粒体相关内质网膜影响阿尔茨海默病与帕金森病的研究进展
Author: Shuangshuang ZHANG ; Shi ZHOU ; Ruiyuan WANG ; Junping LI
From: Chinese Journal of Geriatrics 2021;40(2):250-254
CountryChina
Language:Chinese
Abstract: Alzheimer's disease(AD)and Parkinson's disease(PD)are common neurodegenerative diseases that seriously threaten the health of the elderly, involving various abnormalities in physiology and metabolism including the impairment of mitochondrial function, Ca 2+ homeostasis deregulation, oxidative stress, aggregation of misfolded proteins, autophagy and inflammation.However, mechanisms underlying the pathogenesis of these diseases have not been clearly elucidated, thus impeding advances in their treatment.In recent years, it has been found that mitochondria-associated endoplasmic reticulum membranes(MAM)play an important role in the development of AD and PD and exert their effects by regulating the functions of mitochondria and endoplasmic reticula.This article reviews studies of the past decade related to the effects of MAM on AD and PD, aiming to generate insights for exploring the constituent proteins of MAM and the molecular mechanisms of AD and PD via endoplasmic reticulum-mitochondria Ca 2+ transport and ER stress regulated by MAM.