BRICS report of 2018-2019: the distribution and antimicrobial resistance profile of clinical isolates from blood culture in China
- VernacularTitle:2018至2019年度全国血流感染细菌耐药监测报告
- Author:
Yunbo CHEN
;
Jinru JI
;
Chaoqun YING
;
Peipei WANG
;
Zhiying LIU
;
Qing YANG
;
Haishen KONG
;
Hui DING
;
Yongyun LIU
;
Haifeng MAO
;
Ying HUANG
;
Zhenghai YANG
;
Yuanyuan DAI
;
Guolin LIAO
;
Lisha ZHU
;
Liping ZHANG
;
Yanhong LI
;
Hongyun XU
;
Junmin CAO
;
Baohua ZHANG
;
Liang GUO
;
Haixin DONG
;
Shuyan HU
;
Sijin MAN
;
Lu WANG
;
Zhixiang LIAO
;
Rong XU
;
Dan LIU
;
Yan JIN
;
Yizheng ZHOU
;
Yiqun LIAO
;
Fenghong CHEN
;
Beiqing GU
;
Jiliang WANG
;
Jinhua LIANG
;
Lin ZHENG
;
Aiyun LI
;
Jilu SHEN
;
Yinqiao DONG
;
Lixia ZHANG
;
Hongxia HU
;
Bo QUAN
;
Wencheng ZHU
;
Kunpeng LIANG
;
Qiang LIU
;
Shifu WANG
;
Xiaoping YAN
;
Jiangbang KANG
;
Xiusan XIA
;
Lan MA
;
Li SUN
;
Liang LUAN
;
Jianzhong WANG
;
Zhuo LI
;
Dengyan QIAO
;
Lin ZHANG
;
Lanjuan LI
;
Yonghong XIAO
- From: Chinese Journal of Clinical Infectious Diseases 2021;14(1):32-45
- CountryChina
- Language:Chinese
- Abstract: Objective:To investigate the distribution and antimicrobial resistance profile of clinical bacteria isolated from blood culture in China.Methods:The clinical bacterial strains isolated from blood culture from member hospitals of Blood Bacterial Resistant Investigation Collaborative System (BRICS) were collected during January 2018 to December 2019. Antibiotic susceptibility tests were conducted with agar dilution or broth dilution methods recommended by US Clinical and Laboratory Standards Institute (CLSI). WHONET 5.6 was used to analyze data.Results:During the study period, 14 778 bacterial strains were collected from 50 hospitals, of which 4 117 (27.9%) were Gram-positive bacteria and 10 661(72.1%) were Gram-negative bacteria. The top 10 bacterial species were Escherichia coli (37.2%), Klebsiella pneumoniae (17.0%), Staphylococcus aureus (9.7%), coagulase-negative Staphylococci (8.7%), Pseudomonas aeruginosa (3.7%), Enterococcus faecium (3.4%), Acinetobacter baumannii(3.4%), Enterobacter cloacae (2.9%), Streptococci(2.8%) and Enterococcus faecalis (2.3%). The the prevalence of methicillin-resistant S. aureus (MRSA) and methicillin-resistant coagulase-negative Staphylococcus were 27.4% (394/1 438) and 70.4% (905/1 285), respectively. No glycopeptide-resistant Staphylococcus was detected. More than 95% of S. aureus were sensitive to amikacin, rifampicin and SMZco. The resistance rate of E. faecium to vancomycin was 0.4% (2/504), and no vancomycin-resistant E. faecalis was detected. The ESBLs-producing rates in no carbapenem-resistance E. coli, carbapenem sensitive K. pneumoniae and Proteus were 50.4% (2 731/5 415), 24.6% (493/2001) and 35.2% (31/88), respectively. The prevalence of carbapenem-resistance in E. coli and K. pneumoniae were 1.5% (85/5 500), 20.6% (518/2 519), respectively. 8.3% (27/325) of carbapenem-resistance K. pneumoniae was resistant to ceftazidime/avibactam combination. The resistance rates of A. baumannii to polymyxin and tigecycline were 2.8% (14/501) and 3.4% (17/501) respectively, and that of P. aeruginosa to carbapenem were 18.9% (103/546). Conclusions:The surveillance results from 2018 to 2019 showed that the main pathogens of bloodstream infection in China were gram-negative bacteria, while E. coli was the most common pathogen, and ESBLs-producing strains were in majority; the MRSA incidence is getting lower in China; carbapenem-resistant E. coli keeps at a low level, while carbapenem-resistant K. pneumoniae is on the rise obviously.