Assessment of platelet function using a Platelet Function Analyzer-100 for metabolic syndrome patients

VernacularTitle:血小板功能分析仪-100测定代谢综合征患者血小板功能及其影响因素分析
Author: Tingting WANG ; Li FU ; Yinfeng ZHANG ; Lingling LIU ; Lili MA ; Leilei DING ; Li LI
From: Chinese Journal of Health Management 2021;15(2):163-166
CountryChina
Language:Chinese
Abstract: Objective:Metabolic syndrome (MS) patients and determine factors related to platelet hyperactivation.Methods:A total of 999 participants (822 males and 177 females) were enrolled. Participants were divided into two groups according to the metabolic index: MS group (501) and normal control (NC) group (498). Platelet function was tested with PFA100 (Siemens USA, Deerfield, Illinois) which measures the time it takes for blood to occlude an aperture (closure time, CT) following stimulation with collagen and adenosine diphosphate. Statistical analyses were performed using the SPSS statistical software package, version 22.0 (IBM Corporation, Armonk, NY, USA).Results:MS group had significantly shorter CT values compared with NC group (106.6±27.8s) vs (113.7±27.9s). Higher BMI, WC, BP, TC, TG, LDL-C, UA, and PRL were correlated with shorter CT values (all P<0.05). Conclusion:Our results indicated platelet hyperactivation exists in MS which was related to obesity and elevated blood pressure, blood lipids, uric acid, and PLR.