Research progress of radionuclide labeled fibroblast activation protein targeted molecular probes
10.3760/cma.j.cn321828-20200310-00094
- VernacularTitle:放射性核素标记的成纤维细胞激活蛋白靶向分子探针的研究进展
- Author:
Jianling TAN
;
Xiaoli LAN
;
Yongxue ZHANG
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2021;41(3):180-184
- CountryChina
- Language:Chinese
-
Abstract:
Fibroblast activation protein (FAP) is a marker protein of cancer-associated fibroblasts(CAFs). It is highly expressed in more than 90% of epithelial cancers and hardly expressed in normal tissues. Therefore, FAP is a very promising target. Radionuclide labeled FAP targeted molecular probes can be used for PET or SPECT imaging. In particular, 68Ga-FAP inhibitors (FAPIs) PET/CT has shown good prospects in the clinic, providing a new idea for early diagnosis, accurate staging and radionuclide treatment of tumors. In addition, FAP is also highly expressed in certain non-tumor diseases, especially those related to fibrosis. In this article, the research progress of radionuclide-labeled FAP targeted molecular probes is reviewed.
