Advances development of 64CuCl 2 in the diagnosis and treatment of tumor and disease of abnormal copper metabolism

VernacularTitle:64CuCl 2在肿瘤与铜代谢异常疾病诊疗中的研究进展
Author: Xian LI ; Yunhua WANG ; Xiaowei MA
From: Chinese Journal of Nuclear Medicine and Molecular Imaging 2021;41(2):119-123
CountryChina
Language:Chinese
Abstract: Copper is an essential metal element for human metabolism. Copper homeostasis can lead to inherited disorders of copper metabolism and also play an important role in tumor proliferation. In recent years, great progress has been made in the research and development of radioactive metal nuclide tracers, and molecular imaging quickly becomes a new inspection technology for detecting copper metabolism. 64CuCl 2 carries out PET imaging diagnosis of diseases with abnormal copper metabolism and tumors with high copper metabolism through real-time tracking of changes of copper ions in the body. At the same time, β - decay and electron capture of 64CuCl 2 have a therapeutic effect, and can be directly used for tumor nuclide therapy. Therefore, 64CuCl 2, as an integrated radiopharmaceutical for diagnosis and treatment, is the current research focus of molecular imaging. This article reviews 64CuCl 2 preparation, biological metabolism and its application in the diagnosis and treatment of abnormal copper metabolism diseases and tumors.