OPG-RANKL-RANK pathway: important mechanism of postmenopausal osteoporosis
10.3760/cma.j.cn121113-20210407-00286
- VernacularTitle:OPG-RANKL-RANK信号通路——绝经后骨质疏松症的重要作用机制
- Author:
Qiang LIU
- From:
Chinese Journal of Orthopaedics
2021;41(10):668-674
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis is a common systemic metabolic bone disease, which is mainly characterized by low bone mass and damage of bone microstructure, resulting in increased bone fragility and fracture. With the aging of China's population, osteo-porosis and osteoporotic fracture are seriously threatening people's health. The current status of diagnosis and treatment of osteoporosis in China, the role of OPG-RANKL-RANK signaling pathway in the pathophysiology of osteoporosis, and the research progress of denosumab in the treatment of postmenopausal osteoporosis were studied to provide reference for the clinical practice of postmenopausal osteoporosis.
