Liver tolerogenic dendritic cells and liver transplantation immunity
10.3760/cma.j.cn113884-20200317-00144
- VernacularTitle:肝脏耐受性树突状细胞与肝移植免疫研究进展
- Author:
Longlong WU
;
Hongli SONG
- From:
Chinese Journal of Hepatobiliary Surgery
2021;27(2):149-152
- CountryChina
- Language:Chinese
-
Abstract:
Dendritic cells are the key cells to regulate immunity. Tolerogenic dendritic cells (Tol-DC) with immunosuppressive function play an important role in inducing and maintaining immune tolerance. In recent years, a class of liver Tol-DC with low level of presenting antigen and inhibition of T cell activation and proliferation has become a research hotspot to reduce the rejection of liver transplantation. At the same time, there are many strategies to induce phenotypic stable Tol-DC, which lays a foundation for its clinical application. This article introduces the current understanding of liver Tol-DC and its mechanism of regulating the immunity of liver transplantation, in order to provide new ideas for immunotherapy of liver transplantation.
