Research advances in SULF2 and its relationship with hepatocellular carcinoma

VernacularTitle:硫酸酯酶2与肝细胞癌关系的研究进展
Author: Shaoshan HAN ; Runkun LIU ; Lei HAN ; Qingguang LIU
From: Chinese Journal of Hepatobiliary Surgery 2021;27(1):74-77
CountryChina
Language:Chinese
Abstract: Cell secreted sulfatase 2 is an endogenous sulphate esterase, which can hydrolyze the sulphate groups in extracellular matrix or on the chain of heparan sulphate on the outer surface of cell membrane, which can dissociate the growth factor bound to heparan sulphate proteoglycan, improve the local concentration of growth factor and activate the downstream signal. Sulfatase 2 is highly expressed in a variety of tumors, and the increased expression of sulfatase 2 in hepatocellular carcinoma is associated with poor prognosis. Sulfatase 2 can promote tumor progression by activating multiple signaling pathways in hepatocellular carcinoma cells. Inhibit the activity of hepatocellular carcinoma cell sulfatase 2, and then inhibit the proliferation, migration and tumorigenesis of hepatocellular carcinoma cells. In this paper, the research progress of sulfatase 2 and its role in the occurrence and development of hepatocellular carcinoma is summarized.