Hemodynamic monitoring of the liver after auxillary liver transplantation treated with a functional shunt for portal hypertension associated with a small-for-size graft
10.3760/cma.j.cn113884-20200915-00492
- VernacularTitle:门静脉高压症辅助式肝移植术后肝脏血流动力学变化规律的研究
- Author:
Wei QU
;
Zhijun ZHU
;
Lin WEI
;
Liying SUN
;
Zhigui ZENG
;
Ying LIU
;
Haiming ZHANG
;
Jun WANG
;
Yule TAN
- From:
Chinese Journal of Hepatobiliary Surgery
2021;27(1):42-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the hepatic hemodynamics changes and pathophysiological mechanisms of the use of a functional shunt after auxillary liver transplantation to treat portal hypertension associated with a small-for-size graft.Methods:A retrospective analysis of the clinical data of patients with portal hypertension treated with functional shunting of small-volume grafts from a living donor liver at the Beijing Friendship Hospital, Capital Medical University from July 2014 to December 2018, and a total of 6 patients were included as the research objects, including 4 males and 2 females, with a median age of 35.5 (29.0-52.0) years old. Blood flow monitoring data were collected during and after operation, and the characteristics of liver hemodynamics were analyzed.Results:The portal venous blood flow of the remnant native liver gradually decreased to no flow. As a buffer response, the flow velocity of hepatic artery increased. The portal venous blood flow of the graft gradually increased in the early postoperative period and then gradually decreased from post-operation Day 5 to 10 due to gradual increase in portal venous resistance. However, the portal venous perfusion gradually increased from Day 10 after the operation, reached to a level and declined to a stable level about 1 month after the operation. The volume of abdominal drainage slowly decreased after the peak level at Day 5-10 after the operation, and disappeared completely at Day 30 after operation.Conclusions:When using auxiliary liver transplantation for functional shunting to treat portal hypertension, autologous residual liver can act as a guide buffer for the pressure gradient of portal vein hyperperfusion in liver transplantation, and reach a steady state of blood flow distribution about 1 month after surgery, while relying on autologous remnant liver hepatic artery buffer response prevents small liver syndrome.
